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dapa treatment  (TargetMol)


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    Structured Review

    TargetMol dapa treatment
    Basic parameters in the experimental groups.
    Dapa Treatment, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dapa treatment/product/TargetMol
    Average 93 stars, based on 6 article reviews
    dapa treatment - by Bioz Stars, 2026-03
    93/100 stars

    Images

    1) Product Images from "Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction"

    Article Title: Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction

    Journal: Frontiers in Pharmacology

    doi: 10.3389/fphar.2021.798381

    Basic parameters in the experimental groups.
    Figure Legend Snippet: Basic parameters in the experimental groups.

    Techniques Used:

    Representative photomicrographs of gross finding (A) , HE staining (B) , transmission electron microscopy (C) , and immunoblotting analysis of RIP1-RIP3-MLKL protein in vivo (D) and in vitro (E) . UUO induces a crowd of necrosis within the tubular epithelium (circle) and abscission of microvilli in epithelial cells (arrows), whereas these are improved following administration of Dapa or RIP inhibitor. Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs UUO or H 2 O 2 .
    Figure Legend Snippet: Representative photomicrographs of gross finding (A) , HE staining (B) , transmission electron microscopy (C) , and immunoblotting analysis of RIP1-RIP3-MLKL protein in vivo (D) and in vitro (E) . UUO induces a crowd of necrosis within the tubular epithelium (circle) and abscission of microvilli in epithelial cells (arrows), whereas these are improved following administration of Dapa or RIP inhibitor. Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs UUO or H 2 O 2 .

    Techniques Used: Staining, Transmission Assay, Electron Microscopy, Western Blot, In Vivo, In Vitro, Control

    Representative photomicrographs of immunohistochemistry for 8-OHdG (A) , urine 8-OHdG concentration (B) , immunoblotting analysis of MnSOD and NOX-4 (C) , and intracellular ROS production in H 2 O 2 -treated HK-2 cells with or without Dapa and RIP inhibitors (D) . Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs. UUO or H 2 O 2 .
    Figure Legend Snippet: Representative photomicrographs of immunohistochemistry for 8-OHdG (A) , urine 8-OHdG concentration (B) , immunoblotting analysis of MnSOD and NOX-4 (C) , and intracellular ROS production in H 2 O 2 -treated HK-2 cells with or without Dapa and RIP inhibitors (D) . Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs. UUO or H 2 O 2 .

    Techniques Used: Immunohistochemistry, Concentration Assay, Western Blot, In Vivo, In Vitro, Control

    Representative photomicrographs of immunoblotting analysis of Wnt3 α/β -catenin/GSK-3 β signaling proteins in vivo (A) and in vitro (B) . Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs. UUO or H 2 O 2 ; $ p < 0.05 vs H 2 O 2 +Dapa.
    Figure Legend Snippet: Representative photomicrographs of immunoblotting analysis of Wnt3 α/β -catenin/GSK-3 β signaling proteins in vivo (A) and in vitro (B) . Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs. UUO or H 2 O 2 ; $ p < 0.05 vs H 2 O 2 +Dapa.

    Techniques Used: Western Blot, In Vivo, In Vitro, Control



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    dapa treatment  (TargetMol)
    93
    TargetMol dapa treatment
    Basic parameters in the experimental groups.
    Dapa Treatment, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dapa treatment/product/TargetMol
    Average 93 stars, based on 1 article reviews
    dapa treatment - by Bioz Stars, 2026-03
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    Basic parameters in the experimental groups.

    Journal: Frontiers in Pharmacology

    Article Title: Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction

    doi: 10.3389/fphar.2021.798381

    Figure Lengend Snippet: Basic parameters in the experimental groups.

    Article Snippet: Following acclimatization for 1 week, rats were randomized into one of five groups and treated daily for 7 days: 1) sham group, sham operated rats without treatment; 2) UUO group, UUO rats without treatment; 3) UUO + Dapa group, UUO rats received Dapa treatment (10 mg/kg oral gavage, T2389/461,432–26–8, TargetMOI®) ( ); 4) UUO + necrostatin-1 (Nec-1) group, UUO rats received Nec-1 treatment (2 mg/kg oral gavage, A4213, APExBIO) ( ); 5) UUO + GSK872 group, UUO rats received GSK872 treatment (1 mg/kg intraperitoneal, HY-101872, MedChemExpress) ( ).

    Techniques:

    Representative photomicrographs of gross finding (A) , HE staining (B) , transmission electron microscopy (C) , and immunoblotting analysis of RIP1-RIP3-MLKL protein in vivo (D) and in vitro (E) . UUO induces a crowd of necrosis within the tubular epithelium (circle) and abscission of microvilli in epithelial cells (arrows), whereas these are improved following administration of Dapa or RIP inhibitor. Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs UUO or H 2 O 2 .

    Journal: Frontiers in Pharmacology

    Article Title: Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction

    doi: 10.3389/fphar.2021.798381

    Figure Lengend Snippet: Representative photomicrographs of gross finding (A) , HE staining (B) , transmission electron microscopy (C) , and immunoblotting analysis of RIP1-RIP3-MLKL protein in vivo (D) and in vitro (E) . UUO induces a crowd of necrosis within the tubular epithelium (circle) and abscission of microvilli in epithelial cells (arrows), whereas these are improved following administration of Dapa or RIP inhibitor. Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs UUO or H 2 O 2 .

    Article Snippet: Following acclimatization for 1 week, rats were randomized into one of five groups and treated daily for 7 days: 1) sham group, sham operated rats without treatment; 2) UUO group, UUO rats without treatment; 3) UUO + Dapa group, UUO rats received Dapa treatment (10 mg/kg oral gavage, T2389/461,432–26–8, TargetMOI®) ( ); 4) UUO + necrostatin-1 (Nec-1) group, UUO rats received Nec-1 treatment (2 mg/kg oral gavage, A4213, APExBIO) ( ); 5) UUO + GSK872 group, UUO rats received GSK872 treatment (1 mg/kg intraperitoneal, HY-101872, MedChemExpress) ( ).

    Techniques: Staining, Transmission Assay, Electron Microscopy, Western Blot, In Vivo, In Vitro, Control

    Representative photomicrographs of immunohistochemistry for 8-OHdG (A) , urine 8-OHdG concentration (B) , immunoblotting analysis of MnSOD and NOX-4 (C) , and intracellular ROS production in H 2 O 2 -treated HK-2 cells with or without Dapa and RIP inhibitors (D) . Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs. UUO or H 2 O 2 .

    Journal: Frontiers in Pharmacology

    Article Title: Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction

    doi: 10.3389/fphar.2021.798381

    Figure Lengend Snippet: Representative photomicrographs of immunohistochemistry for 8-OHdG (A) , urine 8-OHdG concentration (B) , immunoblotting analysis of MnSOD and NOX-4 (C) , and intracellular ROS production in H 2 O 2 -treated HK-2 cells with or without Dapa and RIP inhibitors (D) . Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs. UUO or H 2 O 2 .

    Article Snippet: Following acclimatization for 1 week, rats were randomized into one of five groups and treated daily for 7 days: 1) sham group, sham operated rats without treatment; 2) UUO group, UUO rats without treatment; 3) UUO + Dapa group, UUO rats received Dapa treatment (10 mg/kg oral gavage, T2389/461,432–26–8, TargetMOI®) ( ); 4) UUO + necrostatin-1 (Nec-1) group, UUO rats received Nec-1 treatment (2 mg/kg oral gavage, A4213, APExBIO) ( ); 5) UUO + GSK872 group, UUO rats received GSK872 treatment (1 mg/kg intraperitoneal, HY-101872, MedChemExpress) ( ).

    Techniques: Immunohistochemistry, Concentration Assay, Western Blot, In Vivo, In Vitro, Control

    Representative photomicrographs of immunoblotting analysis of Wnt3 α/β -catenin/GSK-3 β signaling proteins in vivo (A) and in vitro (B) . Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs. UUO or H 2 O 2 ; $ p < 0.05 vs H 2 O 2 +Dapa.

    Journal: Frontiers in Pharmacology

    Article Title: Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction

    doi: 10.3389/fphar.2021.798381

    Figure Lengend Snippet: Representative photomicrographs of immunoblotting analysis of Wnt3 α/β -catenin/GSK-3 β signaling proteins in vivo (A) and in vitro (B) . Data are presented as mean ± SEM ( in vivo , n = 6; in vitro , n = 3) and analyzed by one-way ANOVA. *** p < 0.01 vs sham or control; # p < 0.05 vs. UUO or H 2 O 2 ; $ p < 0.05 vs H 2 O 2 +Dapa.

    Article Snippet: Following acclimatization for 1 week, rats were randomized into one of five groups and treated daily for 7 days: 1) sham group, sham operated rats without treatment; 2) UUO group, UUO rats without treatment; 3) UUO + Dapa group, UUO rats received Dapa treatment (10 mg/kg oral gavage, T2389/461,432–26–8, TargetMOI®) ( ); 4) UUO + necrostatin-1 (Nec-1) group, UUO rats received Nec-1 treatment (2 mg/kg oral gavage, A4213, APExBIO) ( ); 5) UUO + GSK872 group, UUO rats received GSK872 treatment (1 mg/kg intraperitoneal, HY-101872, MedChemExpress) ( ).

    Techniques: Western Blot, In Vivo, In Vitro, Control